Publications

(from 2007)

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N. Erlichman, T. Meshel, T. Baram, A. Abu Raiya, T. Horvitz, H. Ben-Yaakov, A. Ben-Baruch

The cell-autonomous pro-metastatic activities of PD-L1 in breast cancer are regulated by N-linked glycosylation-dependent activation of STAT3 and STAT1

Cells, Vol. 12, 2023 (pp. 2338)

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H. Ben-Yaakov, T. Meshel, M. Pasmanik-Chor, C. Körner, A. Ben-Baruch.

A Tumor Microenvironment-Driven Network Regulated by STAT3 and p65 Negatively Controls the Enrichment of Cancer Stem Cells in Human HR+/HER2− Breast Cancer

Cancers, Vol. 15, 2023 (pp. 2255)

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T. Baram, N. Oren, N. Erlichman, T. Meshel, A. Ben-Baruch.

Inflammation-driven regulation of PD-L1 and PD-L2, and their cross-interactions with protective soluble TNFa receptors in human triple-negative breast cancer

Cancers, Vol. 14, 2022 (pp. 3513)

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A. Ben-Baruch.

Tumor Necrosis Factor α: Taking a Personalized Road in Cancer Therapy

Frontiers in Immunology. Vol. 13, 2022 (Article 903679).

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N. Erlichman, T. Baram, T. Meshel, D. Morein, B. Da'adoosh, A. Ben-Baruch. 

Tumor cell-autonomous pro-metastatic activities of PD-L1 in human breast cancer are nediated by PD-L1-S283 and chemokine axes
Cancers. Vol. 14, 2022 (pp. 1042).

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T. Baram, N. Erlichman, M. Dadiani, N. Balint-Lahat, A. Pavlovski, T. Meshel, D. Morzaev-Sulzbach, E. Nili Gal-Yam, I. Barshack, A. Ben-Baruch. 

Chemotherapy shifts the balance in favor of CD8+ TNFR2+ TILs in triple-negative breast tumors

Cells. Vol. 10, 2021 (pp. 1429).
 

D. Morein, L. Rubinstein-Achiasaf, H. Brayer, O. Dorot, E. Pichinuk, H. Ben-Yaakov, T. Meshel, M. Pasmanik-Chor, A. Ben-Baruch.

Continuous inflammatory stimulation leads via metabolic plasticity to a pro-metastatic phenotype in triple-negative breast cancer cells

Cells. Vol. 10, 2021 (pp. 1356).

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L. Rubinstein-Achiasaf, D. Morein, H. Ben Yaakov, Y. Liubomirski, T. Meshel, E. Elbaz, O. Dorot, E. Pichinuk, M. Gershovits, M. Weil, A. Ben-Baruch.

Persistent inflammatory stimulation drives the conversion of MSCs to inflammatory CAFs that promote pro-metastatic characteristics in breast cancer cells

Cancers. Vol. 13, 2021 (pp. 1472).   

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T. Baram*, L. Rubinstein-Achiasaf*, H. Ben Yaakov*, A. Ben-Baruch.

Inflammation-driven breast tumor cell plasticity: Stemness/EMT, therapy resistance and dormancy

Frontiers in Oncology. Vol. 10,  2021 (Article 614468).

*Equal first authorship

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Y. Liubomirski, A. Ben-Baruch.

Inflammation-Notch interactions in regulating cancer progression

Cells. Vol. 9, 2020 (pp. 1576).

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D. Morein*, N. Erlichman*, A. Ben-Baruch.

The expanding roles of chemokines and their receptors in malignancy: Far beyond tumor and immune cell migration

Frontiers in Immunology. Vol. 11, 2020 (Article 952).

*Equal first authorship.

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M. Dadiani, D. Necula, S. Kahana-Edwin, N. Oren, T. Baram, I. Marin, D. Morzaev-Sulzbach, A. Pavlovski, N. Balint-Lahat, 

L. Anafi, S. Wiemann, C. Korner, E. Nili Gal-Yam, C. Avivi, B. Kaufman, I. Barshack, A. Ben-Baruch.

TNFR2+ TILs are significantly associated with improved survival in triple-negative breast cancer patients

Cancer Immunology, Immunotherapy. Vol. 69, 2020 (pp. 1315-1326)

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A. Ben-Baruch.

Partners in crime: TNFα-based networks promoting cancer progression and their clinical implications

Cancer Immunology, Immunotherapy. Vol. 69, 2020 (pp. 263–273)

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N. Ershaid, Y. Sharon, H. Schwartz, Y. Raz, O. Shani, N. Cohen, L. Monteran, L. Leider-Trejo, M. Yassin, A. Ben-Shmuel, M. Gerlic, A. Ben-Baruch, M. Pasmanik-Chor, R.N. Apte, N. Erez.

NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis

Nature Communications. Vol. 10, 2019 (pp. 4375-4389)

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Y. Liubomirski, S. Lerrer, T. Meshel, D. Morein, L. Rubinstein-Achiasaf, D. Sprinz, S. Weiman, C. Körner, M. Ehrlich, A. Ben-Baruch.

Notch-Mediated Tumor-Stroma-Inflammation Networks Promote Invasive Properties and CXCL8 Expression in Triple-Negative Breast Cancer

Frontiers in Immunology. Vol. 10, 2019 (Article 804).

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Y. Liubomirski, S. Lerrer, T. Meshel, L. Rubinstein-Achiasaf, D. Morein, S. Weiman, C. Körner, A. Ben-Baruch.

Tumor-Stroma-Inflammation Networks Promote Pro-metastatic Chemokines and Aggressiveness Characteristics in Triple-Negative Breast Cancer

Frontiers in Immunology. Vol. 10, 2019 (Article 757).

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S. Lerrer, Y. Liubomirski, A. Bott, K. Abnaof, N. Oren, A. Yousaf, C. Körner, T. Meshel, S. Wiemann, A. Ben-Baruch.
Co-inflammatory roles of TGFβ1 in the presence of TNFα drive a pro-inflammatory fate in mesenchymal stem cells

Front. Immunol. Vol. 11, 2017 (Article 479).

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A. Bott, N. Erdem, S. Lerrer, A. Hotz-Wagenblatt, C. Breunig, K. Abnaof, A. Wörner, H. Wilhelm, E. Münstermann,
A. Ben-Baruch, S. Wiemann.

miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A

Oncotarget. Vol. 8, 2017 (pp: 43897-43914).

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P. Weitzenfeld, T. Meshel, A. Ben-Baruch

Microenvironmental networks promote tumor heterogeneity and enrich for metastatic cancer stem-like cells
in Luminal-A breast tumor cells

Oncotarget. Vol. 7, 2016 (pp: 81123-81143). 

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D. Netanely , A. Avraham , A. Ben-Baruch , E. Evron and R. Shamir

Expression and methylation patterns partition luminal-A breast tumors into distinct prognostic subgroups

Breast Cancer Research. Vol. 18, 2016 (pp: 74-89).

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P. Weitzenfeld, O. Kossover, C. Körner, T. Meshel, S. Wiemann, D. Seliktar, D.F. Legler, A. Ben-Baruch.

Chemokine axes in breast cancer: factors of the tumor microenvironment reshape the CCR7-driven metastatic spread of luminal-A breast tumors

J Leukoc Biol. Vol. 99, 2016 (pp. 1009-1025). 

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C. Katanov, S. Lerrer, Y. Liubomirski, L. Lieder-Trejo, T. Meshel, J. Bar, R. Feniger-Barish, I. Kamer, G. Soria-Artzi, H. Kahani, D. Banerjee, A. Ben-Baruch

Regulation of the inflammatory profile of stromal cells in human breast cancer: Prominent roles for TNF-alpha and the NF-kappaB pathway 

Stem Cell Research & Therapy. Vol. 6, 2015 (pp. 87-104).

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Y. Lebel-Haziv, T. Meshel, G. Soria, A. Yeheskel , E. Mamon, A. Ben-Baruch.

Breast cancer: Coordinated regulation of CCL2 secretion by intracellular glycosaminoglycans and chemokine motifs.

Neoplasia. Vol. 16, 2014 (pp. 723-740).

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P. Weitzenfeld, A. Ben-Baruch.

The chemokine system, and its CCR5 and CXCR4 receptors, as potential targets for personalized therapy in cancer.

Cancer Letters. Vol. 352, 2014 (pp. 36-53).

 

T. Leibovich-Rivkin, Y. Liubomirski, T. Meshel, A. Abashidze D. Brisker, H. Solomon, V. Rotter, M. Weil, A. Ben-Baruch.

The inflammatory cytokine TNFa cooperates with hyper-activated Ras in promoting metastasis and turns WT-Ras into an oncogenic entity in MCF-7 cells.

BMC Cancer. Vol. 14, 2014 (pp. 158-176). 

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F. Bachelerie, A. Ben-Baruch*, A.M. Burkhardt, C. Combadiere, J.M. Farber, G. J. Graham, R. Horuk, A.H. Sparre-Ulrich, M. Locati, A.D. Luster, A. Mantovani, K. Matsushima, P.M. Murphy, R. Nibbs, H.  Nomiyama, C.A. Power, A.E. I. Proudfoot, M.M. Rosenkilde, A. Rot, S. Sozzani, M. Thelen, O. Yoshie, A. Zlotnik.

Update on the Extended Family of Chemokine Receptors and introducing a new nomenclature for atypical chemokine receptors.

Pharmacological Reviews. Vol. 66, 2014 (pp. 1-79). 

*Equal contribution of all authors (arranged by alphabetical order).

 

T. Leibovich-Rivkin, Y. Liubomirski, B. Bernstein, T. Meshel, A. Ben-Baruch.

Inflammatory factors of the tumor microenvironment induce plasticity in non-transformed breast epithelial cells: EMT, invasion and collapse of normally-organized breast textures.

Neoplasia. Vol. 15, 2013 (pp. 1330-1346).

 

P. Weitzenfeld, N. Meron , T. Leibovich-Rivkin, T. Meshel, A. Ben-Baruch

Progression of luminal breast tumors is promoted by Ménage-a-trois between the inflammatory cytokine TNFa and the hormonal and growth-supporting arms of the tumor microenvironment.

Mediators of Inflammation. Vol, 2013 (Article ID. 720536).

 

G. Soria, Y. Lebel-Haziv, M. Ehrlich, T. Meshel, E. Avezov, P. Rozenberg, A. Ben-Baruch.

Mechanisms regulating the secretion of the pro-malignancy chemokine CCL5 by breast tumor cells: CCL5’s 40s loop and intracellular glycosaminoglycans. Neoplasia. Vol. 14, 2012 (pp. 1-19).

 

T. Leibovitz-Rivkin, Y. Buganim, H. Solomon, T. Meshel, V. Rotter, A. Ben-Baruch.

Tumor-promoting circuits that regulate a cancer-related chemokine cluster: Dominance of inflammatory mediators over oncogenic alterations.

Cancers. Vol. 4, 2012 (pp. 55-76).

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T. Leibovitch-Rivkin, Y. Lebel-Haziv*, S. Lerrer*, P. Weitzenfeld*, A. Ben-Baruch.

The versatile world of inflammatory chemokines in cancer. In: “The Tumor Immunoenvironment”. M.R. Shurin, V. Umansky, A. Malyguine, (Editors)

Springer Publishers. 2012.

*Equal contribution.

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A. Ben-Baruch.

The tumor-promoting flow of cells into, within and out of the tumor site: Regulation by the inflammatory axis of TNFa and chemokines.

Cancer Microenvironment. Vol  5, 2012 (pp. 151-164).

 

Z. Shulman, S.J. Cohen, B. Roediger, V. Kalchenko, R. Jain, V. Grabovsky, E. Klein, V. Shinder, L.  Stoler-Barak, S.W. Feigelson, T. Meshel, S. M. Nurmi, I. Goldstein, O. Hartley, C.G. Gahmberg, A. Etzioni, W. Weninger, A. Ben-Baruch, R. Alon.

Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than extracellular chemokine depots.

Nature Imm. Vol. 13, 2011 (pp. 67-76).

 

G. Soria, M. Ofri-Shahak, I. Haas, N. Yaal-Hahoshen, L. Leider-Trejo, T. Leibovich-Rivkin, P. Weitzenfeld, T. Meshel, E. Shabtai, , M. Gutman, A. Ben-Baruch. Inflammatory mediators in breast cancer: Coordinated expression of TNFa & IL-1b with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition.

BMC Cancer. Vol. 11, 2011 (pp. 130-149).

 

K. Haim, P. Weitzenfeld, T. Meshel, A. Ben-Baruch.

EGF and estrogen act by independent pathways to additively promote the release of the angiogenic chemokine CXCL8 by breast tumor cells.

Neoplasia. Vol. 13, 2011 (pp. 230-243).

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P. Mishra, D. Banerjee, A. Ben-Baruch.

Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancy.  

J. Leuk. Biol. Vol. 89, 2011 (pp. 31-39). 

 

R. Mintz, B. Garty, T. Meshel, N. Marcus, C. Katanov, E. Cohen-Hillel, A. Ben-Baruch.

Reduced expression of chemoattractant receptors by polymorphonuclear leukocytes in Hyper IgE Syndrome patients.

Imm. Letters. Vol. 130, 2010 (pp. 97-106).

 

B. Garty, A. Ben-Baruch, A. Rolinsky, C. Woellner, B. Grimbacher, N. Marcus.

Pneumocystis jirovecii pneumonia in a baby with hyper-IgE syndrome.

Eur. J. Pediatrics. Vol. 169, 2010 (pp. 35-37).

 

Cohen-Hillel, T. Meshel, R. Mintz, B.-Z. Garty, A. Ben-Baruch.

Cell migration to the chemokine CXCL8: Paxillin is activated and regulates adhesion and cell motility.

Cell Mol. Life Sciences. Vol. 66, 2009 (pp. 884-899).

 

Soria, T. Meshel, A. Ben-Baruch.

Chemokines in human breast tumor cells: Modifying their expression levels and determining their effects on the malignancy phenotype.

Methods Enzymol. Vol. 460, 2009 (pp. 3-16).

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A. Ben-Baruch.

Site-specific metastasis formation: Chemokines as regulators of tumor cell adhesion, motility and invasion.

Cell Adhesion & Migration. Vol. 3, 2009 (pp 328-333).

 

A. Ben-Baruch.

Topic Page. Chemokines in malignancy: Multifaceted roles and implications in tumor growth and metastasis.

Elsevier’s Scirus Electronic Page. 2009.

 

A. Ben-Baruch.

Editor of a Review Book: Breast cancer: From pathogenesis to potential therapeutic modalities. In: "Clinical Cancer Research". A. Ben-Baruch (Editor),

Transworld Research Network. 2009.

 

G. Soria and A. Ben-Baruch.

The CCL5/CCR5 axis in cancer. In: Book Series "Cancer Drug Discovery and Development - Chemokine Receptors in Cancer” A. Fulton (Editor).

Springer Publishers. 2009 (pp. 109-130).

 

I. Nevo, O. Sagi-Assif, T. Meshel, A. Ben-Baruch, K Jöhrer, R. Greil, L.E. Leider Trejo, O. Kharenko, M. Feinmesser, I. Yron, I.P. Witz.

The involvement of the fractalkine receptor in the trans migration of neuroblastoma cells through bone marrow endothelial cells.

Cancer Letters. Vol. 273, 2009 (pp. 127-139).

 

Soria, N. Yaal-Hahoshen, E. Azenshtein, S. Shina, L. Leider-Trejo, L. Rivo, E. Cohen-Hillel, A. Shtabsky, M. Ehrlich, T. Meshel, I. Keydar, A. Ben-Baruch.

Concomitant expression of the chemokines RANTES and MCP-1 in human breast cancer: A basis for tumor-promoting interactions.

Cytokine. Vol. 44, 2008 (pp. 191-200).

 

H. Attal, E. Cohen-Hillel, T. Meshel, J.M Wang, W. Gong, A. Ben-Baruch.

Intracellular cross-talk between the GPCR CXCR1 and CXCR2: Role of carboxyl terminus phosphorylation sites.

Exp. Cell. Res. Vol. 314, 2008 (pp. 352-365).

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G. Soria and A. Ben-Baruch.

The inflammatory chemokines CCL2 and CCL5 in breast cancer.

Cancer Letters. Vol. 267, 2008 (pp. 271-285).

 

A. Ben-Baruch.

Organ selectivity in metastasis: Regulation by chemokines and their receptors.

Clin. Exp. Metastasis. Vol. 25, 2008 (pp. 345-356).

 

A. Ben-Baruch.

Expert commentary: The chemokine receptor CXCR3 and its ligands in malignancy: Do they act as double-edged swords? In: "Chemokine Research Trends".

L.R Grinwald (Editor).

Nova Science Publishers. 2008.

 

A. Zipin-Roitman, T. Meshel, O. Sagi-Assif, B. Shalmon, C. Avivi, R.M. Pfeffer, I.P. Witz, A. Ben-Baruch.

CXCL10 promotes invasion-related properties in human colorectal carcinoma cells.

Cancer Res. Vol. 67, 2007 (pp. 3396-3405).

 

E. Cohen-Hillel, I. Yron, T. Meshel, A. Ben-Baruch.

The chemokine interleukin 8 and cell migration to inflammatory sites: The regulation of Focal Adhesion Kinase under conditions of migratory desensitization.

IMAJ. Vol. 9, 2007 (pp. 579-583).